Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults.

ABSTRACT:

Objective

Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models.

Results

Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45-4.06% across various genetic m

SUBMITTER: Al-Jawadi AA 

PROVIDER: S-EPMC8574008 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature