Changes in T and B cell subsets in end stage renal disease patients before and after kidney transplantation.

ABSTRACT:

Background

The incidence of kidney transplantation performed in elderly patients has increased steadily recently. Higher risk of infection and mortality, but lower rate of rejection, are reported in older kidney transplant patients. This study aims to analyze the effect of transplantation on aging of T and B cells in kidney transplant patients, with the emphasis on age and Cytomegalovirus (CMV) latency.

Results

We included 36 patients before and after (median 2.7 years) kidney transplantation and 27 age- and sex-matched healthy controls (HC). T and B cell subsets were measured by flow cytometry, with a focus on aged T cells (CD28-), and age associated B cells (ABCs, CD19 + CD21-CD11c+). Three years after transplantation a significant increase of total T cells among the lymph

SUBMITTER: Wang L 

PROVIDER: S-EPMC8574047 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature