Polygenic risk score across distinct colorectal cancer screening outcomes: from premalignant polyps to colorectal cancer.

ABSTRACT:

Background

Different risk-based colorectal cancer (CRC) screening strategies, such as the use of polygenic risk scores (PRS), have been evaluated to improve effectiveness of these programs. However, few studies have previously assessed its usefulness in a fecal immunochemical test (FIT)-based screening study.

Methods

A PRS of 133 single nucleotide polymorphisms was assessed for 3619 participants: population controls, screening controls, low-risk lesions (LRL), intermediate-risk (IRL), high-risk (HRL), CRC screening program cases, and clinically diagnosed CRC cases. The PRS was compared between the subset of cases (n = 648; IRL+HRL+CRC) and controls (n = 956; controls+LRL) recruited within a FIT-based screening program. Positive predictive values (PPV), negative predictive va

SUBMITTER: Obon-Santacana M 

PROVIDER: S-EPMC8574048 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature