Association between preoperative serum homocysteine and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a prospective observational study.

ABSTRACT:

Background

Homocysteine, folate, and vitamin B₁₂ involved in 1-carbon metabolism are associated with cognitive disorders. We sought to investigate the relationships between these factors and delayed neurocognitive recovery (dNCR) after non-cardiac surgery.

Methods

This was a prospective observational study of patients (n = 175) who were ≥ 60 years of age undergoing non-cardiac surgery. Patients were evaluated preoperatively and for 1 week postoperatively by using neuropsychological tests and were divided into dNCR or non-dNCR groups according to a Z-score ≤ - 1.96 on at least two of the tests. The relationship between the occurrence of dNCR and preoperative levels of homocysteine, folate, and vitamin B₁₂ was analyzed. Univariate and multivariable logist

SUBMITTER: Zhang ZF 

PROVIDER: S-EPMC8574052 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature