Identification of differentially expressed genomic repeats in primary hepatocellular carcinoma and their potential links to biological processes and survival.

ABSTRACT: Hepatocellular carcinoma (HCC) is one of the deadliest cancers. Research on HCC so far primarily focused on genes and provided limited information on genomic repeats, which constitute more than half of the human genome and contribute to genomic stability. In line with this, repeat dysregulation was significantly shown to be pathological in various cancers and other diseases. In this study, we aimed to determine the full repeat expression profile of HCC for the first time. We utilised two independent RNA-seq datasets obtained from primary HCC tumours with matched normal tissues of 20 and 17 HCC patients, respectively. We quantified repeat expressions and analysed their differential expression. We also identified repeats that are cooperatively expressed with genes by constructing a gene coex

SUBMITTER: Karakulah G 

PROVIDER: S-EPMC8574195 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature