CSF-resident CD4⁺ T-cells display a distinct gene expression profile with relevance to immune surveillance and multiple sclerosis.

ABSTRACT: The CNS has traditionally been considered an immune privileged site, but is now understood to have a system of immune surveillance, predominantly involving CD4⁺ T-cells. Identifying functional differences between CNS and blood CD4⁺ T-cells, therefore, have relevance to CNS immune surveillance as well as to neurological conditions, such as multiple sclerosis, in which CD4⁺ T-cells play a central role. Here, CD4⁺ T-cells were purified from CSF and blood from 21 patients with newly diagnosed treatment-naïve multiple sclerosis and 20 individuals with non-inflammatory disorders using fluorescence-activated cell sorting, and their transcriptomes were profiled by RNA sequencing. Paired comparisons between CD4⁺ T-cells from CSF and blood ident

SUBMITTER: Hrastelj J 

PROVIDER: S-EPMC8574295 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature