An investigation of cross-sectional associations of a priori-selected dietary components with circulating bile acids.

ABSTRACT:

Background

A growing body of literature suggests chronically higher bile acid (BA) concentrations may be associated with multiple health conditions. Diet may affect BA metabolism and signaling; however, evidence from human populations is lacking.

Objectives

We systematically investigated cross-sectional associations of a priori-selected dietary components (fiber, alcohol, coffee, fat) with circulating BA concentrations.

Methods

We used targeted, quantitative LC-MS/MS panels to measure 15 circulating BAs in a subset of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC; n = 2224) and Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO; n = 986) comprising Finnish male smokers and United States men and women, respectively. We used multiva

SUBMITTER: Byrd DA 

PROVIDER: S-EPMC8574696 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature