ProtCHOIR: a tool for proteome-scale generation of homo-oligomers.

ABSTRACT: The rapid developments in gene sequencing technologies achieved in the recent decades, along with the expansion of knowledge on the three-dimensional structures of proteins, have enabled the construction of proteome-scale databases of protein models such as the Genome3D and ModBase. Nevertheless, although gene products are usually expressed as individual polypeptide chains, most biological processes are associated with either transient or stable oligomerisation. In the PDB databank, for example, ~40% of the deposited structures contain at least one homo-oligomeric interface. Unfortunately, databases of protein models are generally devoid of multimeric structures. To tackle this particular issue, we have developed ProtCHOIR, a tool that is able to generate homo-oligomeric structures in an a

SUBMITTER: Torres PHM 

PROVIDER: S-EPMC8574958 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature