The multicellular signalling network of ovarian cancer metastases.

ABSTRACT:

Background

Transcoelomic spread is the major route of metastasis of ovarian high-grade serous carcinoma (HGSC) with the omentum as the major metastatic site. Its unique tumour microenvironment with its large populations of adipocytes, mesothelial cells and immune cells establishes an intercellular signaling network that is instrumental for metastatic growth yet poorly understood.

Methods

Based on transcriptomic analysis of tumour cells, tumour-associated immune and stroma cells we defined intercellular signaling pathways for 284 cytokines and growth factors and their cognate receptors after bioinformatic adjustment for contaminating cell types. The significance of individual components of this network was validated by analysing clinical correlations and potentially pro-metas

SUBMITTER: Sommerfeld L 

PROVIDER: S-EPMC8574964 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature