Ontology highlight
ABSTRACT:
SUBMITTER: Hao Z
PROVIDER: S-EPMC8575042 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Hao Zhiyu Z Gao Jin J Song Yuxin Y Yang Runqing R Liu Di D
Briefings in bioinformatics 20211101 6
In genome-wide mixed model association analysis, we stratified the genomic mixed model into two hierarchies to estimate genomic breeding values (GBVs) using the genomic best linear unbiased prediction and statistically infer the association of GBVs with each SNP using the generalized least square. The hierarchical mixed model (Hi-LMM) can correct confounders effectively with polygenic effects as residuals for association tests, preventing potential false-negative errors produced with genome-wide ...[more]