Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases.

ABSTRACT: Current practice in IBD is to classify patients based on clinical signs and symptoms and provide treatments accordingly. However, the response of IBD patients to available treatments is highly variable, highlighting clinically significant heterogeneity among patients. Thus, more accurate patient stratification is urgently needed to more effectively target therapeutic interventions to specific patients. Here we review the degree of heterogeneity in IBD, discussing how the microbiota, genetics, and immune system may contribute to the variation among patients. We highlight how molecular heterogeneity may relate to clinical phenotype, but in other situations may be independent of clinical phenotype, encouraging future studies to fill the gaps. Finally, we discuss novel stratification methodolo

SUBMITTER: Selin KA 

PROVIDER: S-EPMC8575046 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature