Ontology highlight
ABSTRACT:
SUBMITTER: Dey S
PROVIDER: S-EPMC8575123 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Dey Sucharita S Levy Emmanuel D ED
Structure (London, England : 1993) 20210913 11
An accurate understanding of biomolecular mechanisms and diseases requires information on protein quaternary structure (QS). A critical challenge in inferring QS information from crystallography data is distinguishing biological interfaces from fortuitous crystal-packing contacts. Here, we employ QS conservation across homologs to infer the biological relevance of hetero-oligomers. We compare the structures and compositions of hetero-oligomers, which allow us to annotate 7,810 complexes as physi ...[more]