Dataset Information

Inpatient compliance with venous thromboembolism prophylaxis after orthopaedic trauma: results from a randomized controlled trial of aspirin versus low molecular weight heparin.

ABSTRACT:

Objectives

To compare inpatient compliance with venous thromboembolism prophylaxis regimens.

Design

A secondary analysis of patients enrolled in the ADAPT (A Different Approach to Preventing Thrombosis) randomized controlled trial.

Setting

Level I trauma center.

Patients/participants

Patients with operative extremity or any pelvic or acetabular fracture requiring venous thromboembolism prophylaxis.

Intervention

We compared patients randomized to receive either low molecular weight heparin (LMWH) 30 mg or aspirin 81 mg BID during their inpatient admission.

Main outcome measurements

The primary outcome measure was the number of doses missed compared with prescribed number of doses.

Results

A total of 329 patients were randomized to receive either LMWH 30 mg BID (164 patients) or aspirin 81 mg BID (165 patients). No differences observed in percentage of patients who missed a dose (aspirin: 41.2% vs LMWH: 43.3%, P = .7) or mean number of missed doses (0.6 vs 0.7 doses, P = .4). The majority of patients (57.8%, n = 190) did not miss any doses. Missed doses were often associated with an operation.

Conclusions

These data should reassure clinicians that inpatient compliance is similar for low molecular weight heparin and aspirin regimens.

SUBMITTER: Haac BE

PROVIDER: S-EPMC8575420 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Inpatient compliance with venous thromboembolism prophylaxis after orthopaedic trauma: results from a randomized controlled trial of aspirin versus low molecular weight heparin.

Haac Bryce E BE O'Hara Nathan N NN Manson Theodore T TT Slobogean Gerard P GP Castillo Renan C RC O'Toole Robert V RV Stein Deborah M DM

OTA international : the open access journal of orthopaedic trauma 20210915 4

<h4>Objectives</h4>To compare inpatient compliance with venous thromboembolism prophylaxis regimens.<h4>Design</h4>A secondary analysis of patients enrolled in the ADAPT (A Different Approach to Preventing Thrombosis) randomized controlled trial.<h4>Setting</h4>Level I trauma center.<h4>Patients/participants</h4>Patients with operative extremity or any pelvic or acetabular fracture requiring venous thromboembolism prophylaxis.<h4>Intervention</h4>We compared patients randomized to receive either ...[more]

PMID: 34765900

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Dataset Information

Inpatient compliance with venous thromboembolism prophylaxis after orthopaedic trauma: results from a randomized controlled trial of aspirin versus low molecular weight heparin.

Objectives

Design

Setting

Patients/participants

Intervention

Main outcome measurements

Results

Conclusions

Publications

Inpatient compliance with venous thromboembolism prophylaxis after orthopaedic trauma: results from a randomized controlled trial of aspirin versus low molecular weight heparin.

Similar Datasets

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