Characteristics of upper urinary tract urothelial carcinoma in the context of bladder cancer: a narrative review.

ABSTRACT: Urothelial carcinomas (UC) arise from the urothelium that covers the proximal urethra, urinary bladder, and the upper urinary tract. In daily routine and clinical trials UC originating from different locations are often treated and investigated in the same manner. However, differences between the two locations seem to be apparent and may question in handling them as a single oncologic entity. In this review we discuss similarities and differences between bladder and upper urinary tract UC and consider their potential impact on treatment strategies. Despite similarities of UC in the bladder (BC) and the upper urinary tract (UTUC), clinicopathologic and molecular differences may question to generally assemble both as a single tumor entity. Treatment standards for UTUC are often adopted from

SUBMITTER: Giudici N 

PROVIDER: S-EPMC8575564 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature