Update on systemic treatment of upper tract urothelial carcinoma: a narrative review of the literature.

ABSTRACT: Urothelial cancer (UC) is most commonly found in the urinary bladder, but can also appear in the upper urinary tract, where it is associated with several disease-specific challenges affecting its diagnosis, clinical staging, surgical management, and systemic therapy. A significant number of patients experience extra-vesical disease recurrence despite radical nephroureterectomy (RNU), leading to inevitable demise. Over the last years, the therapeutic armamentarium of UC has expanded with several systemic treatment options entering clinical care and deliver the potential to support a more individualized treatment in the near future. Currently, novel targeted therapies are emerging, accompanied with extensive biomarker research, which leads to a better understanding of the disease and therefo

SUBMITTER: Gust KM 

PROVIDER: S-EPMC8575594 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature