BDNF Genetic Variant and Its Genotypic Fluctuation in Major Depressive Disorder.

ABSTRACT: Major depressive disorder (MDD) still has an unknown etiology and mechanisms. Many studies have been conducted seeking to associate and understand the connection of different genetic variants to this disease. Researchers have extensively studied the brain-derived neurotrophic factor (BDNF) Val66Met genetic variant in MDD; yet, their findings remain inconsistent. This systematic review sought to verify the GG (Val/Val) genotype frequency fluctuation in different populations with MDD. For this, we searched in different databases and, after applying the eligibility criteria, selected 17 articles. Most studies demonstrate the higher frequency of the ancestral (wild) GG (Val/Val) genotype, although associations of the polymorphic A (Met) allele, changes in BDNF protein serum levels, or both wer

SUBMITTER: Ferreira Fratelli C 

PROVIDER: S-EPMC8575598 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature