Na⁺/H⁺-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer.

ABSTRACT:

Background

The acidic characteristics of the tumor microenvironment (TME) are attributed to cancer cells' needs of metabolism which produce a large amount of H⁺. In order not to affect its own life activities, it needs to release H⁺ into the intercellular space through an efficient Na⁺/H⁺ exchanger. On account of the intestine whose physiological function is highly dependent on intestinal pH value, NHE family members may play a critical role in the occurrence and development of colorectal cancer (CRC).

Methods

TCGA, GEPIA2, ONCOMINE, UALCAN, STRING, TIMER, Cytoscape, TargetScan, ENCORI, LncBase v.2, DNMIVD, HPA, and CellMiner^TM databases were used in our study.

Results

The mRNA expressions of SLC9A1, SLC9A2, SLC9A

SUBMITTER: Zhou X 

PROVIDER: S-EPMC8575632 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature