Is sleeve lobectomy safe after induction therapy?-a systematic review and meta-analysis.

ABSTRACT:

Background

Sleeve lobectomy (SL) is a lung-sparing procedure, which is accepted as a valid operation for centrally-located advanced tumors. These tumors often require induction treatment by chemotherapy and/or radiotherapy to downstage the disease and thus facilitate subsequent surgery. However, induction therapy may potentially increase the risk of bronchial anastomotic complications and related morbidity. This meta-analysis aims to determine the impact of induction therapy on the outcomes of pulmonary SL.

Methods

We compared studies of patients undergoing SL or bilobectomy for non-small cell lung cancer (NSCLC) with and without induction therapy. Outcomes of interest were in-hospital mortality, morbidity, anastomosis complication and 5-year survival. Odds ratio (OR) were c

SUBMITTER: Chriqui LE 

PROVIDER: S-EPMC8575812 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature