Long-term radiation therapy-related risk of second primary malignancies in patients with lung cancer.

ABSTRACT:

Background

With the improvement of cancer therapy, a second primary malignancy (SPM) occurs more commonly among cancer survivors. At present, it remains unclear whether the radiation therapy for the initial lung cancer will increase the risk of developing a SPM. This study aims to investigate the long-term risk of a SPM attributable to the radiation therapy in patients with the initial lung cancer.

Methods

Patients initially diagnosed with lung cancer between January 1975 and November 2011 were identified from the Surveillance, Epidemiology, and End Results (SEER) database. SPM was defined as the occurrence of a second cancer at least five years after the diagnosis of the initial lung cancer. Age- and propensity score matching (PSM)-adjusted competing risk analyses were perf

SUBMITTER: Han C 

PROVIDER: S-EPMC8575836 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature