Reappraisal of bone scintigraphy as a new tool for the evaluation of disease activity in patients with rheumatoid arthritis.

ABSTRACT: We aimed to compare the reliability of bone scintigraphy (BS) and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)-derived parameters in the detection of active arthritis in 28-joint areas and evaluate the reliability of joint counts between BS and clinical assessment in patients with rheumatoid arthritis (RA). We enrolled 106 patients (67 in the development group and 39 in the validation groups) with active RA who underwent BS, ¹⁸F-FDG PET/computed tomography (CT), and clinical evaluation of disease activity. We compared the results of BS-derived joint assessment with those of PET-derived and clinical joint assessments. Subsequently we developed a disease activity score (DAS) using BS-positive joints and validated it in an independent group

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC8575878 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature