Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses.

ABSTRACT: Influenza viruses cause a significant number of infections and deaths annually. In addition to seasonal infections, the risk of an influenza virus pandemic emerging is extremely high owing to the large reservoir of diverse influenza viruses found in animals and the co-circulation of many influenza subtypes which can reassort into novel strains. Development of a universal influenza vaccine has proven extremely challenging. In the absence of such a vaccine, rapid response technologies provide the best potential to counter a novel influenza outbreak. Here, we demonstrate that a modular trimerization domain known as the molecular clamp allows the efficient production and purification of conformationally stabilised prefusion hemagglutinin (HA) from a diverse range of influenza A subtypes. These

SUBMITTER: McMillan CLD 

PROVIDER: S-EPMC8575991 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature