Characterisation of insomnia as an environmental risk factor for asthma via Mendelian randomization and gene environment interaction.

ABSTRACT: Asthma is a complex disease that is reportedly associated with insomnia. However, the causal directionality of this association is still unclear. We used asthma and insomnia-associated single nucleotide polymorphisms (SNPs) and genome-wide association study (GWAS) summary statistics to test the causal directionality between insomnia and asthma via Mendelian randomization (MR) analysis. We also performed a cross-trait meta-analysis using UK Biobank GWAS summary statistics and a gene-environment interaction study using data from UK Biobank. The interaction of genetic risk score for asthma (GRS_asthma) with insomnia on asthma was tested by logistic regression. Insomnia was a risk factor for the incidence of asthma, as revealed by three different methods of MR analysis. However, asth

SUBMITTER: Kim DJ 

PROVIDER: S-EPMC8576024 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature