Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels.

ABSTRACT: Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bact

SUBMITTER: Bhubhanil S 

PROVIDER: S-EPMC8576043 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature