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Bispecific antibodies for the treatment of breast cancer.

ABSTRACT:

Introduction

There are more than two dozen bispecific antibodies (BsAbs) in development with a variety of designs which are relevant to breast cancer. The field of BsAbs for breast cancer includes agents that co-direct immune recognition of the cancer cell, target unique cancer antigens, and target the microenvironment. BsAbs are being developed for use as antibody-drug conjugates and as homing signals for engineered T-cells.

Areas covered

This review covers potential targets for bispecific antibodies, agents in pre-clinical development, agents in clinical trials, combinatorial therapies, and future directions.

Expert opinion

There is no BsAb approval expected for breast cancer in the near term, but late-stage trials are underway. Future BsAb roles in breast cancer are possible given unmet needs in estrogen receptor+ disease, residual disease, and de-escalating chemotherapy use. The HER2+ space shows hints of success for BsAbs, but is already crowded. Areas of unmet need still exist.

SUBMITTER: Dillon PM

PROVIDER: S-EPMC8576064 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature

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Bispecific antibodies for the treatment of breast cancer.

Dillon Patrick M PM Tushir-Singh Jogender J Lum Lawrence G LG

Expert opinion on biological therapy 20210509 8

<h4>Introduction</h4>There are more than two dozen bispecific antibodies (BsAbs) in development with a variety of designs which are relevant to breast cancer. The field of BsAbs for breast cancer includes agents that co-direct immune recognition of the cancer cell, target unique cancer antigens, and target the microenvironment. BsAbs are being developed for use as antibody-drug conjugates and as homing signals for engineered T-cells.<h4>Areas covered</h4>This review covers potential targets for ...[more]

PMID: 33896311

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