Sugammadex, neostigmine and postoperative pulmonary complications: an international randomised feasibility and pilot trial.

ABSTRACT:

Background

Sugammadex reduces residual neuromuscular blockade after anaesthesia, potentially preventing postoperative pulmonary complications. However, definitive evidence is lacking. We therefore conducted a feasibility and pilot trial for a large randomised controlled trial of sugammadex, neostigmine, and postoperative pulmonary complications.

Methods

Patients aged ≥40 years having elective or expedited abdominal or intrathoracic surgery were recruited in Australia and Hong Kong. Perioperative care was at the discretion of clinicians, except for the use of rocuronium and/or vecuronium for neuromuscular blockade and the randomised intervention (sugammadex or neostigmine) for reversal. Feasibility measurements included recruitment, crossover, acceptability, completeness, and

SUBMITTER: Leslie K 

PROVIDER: S-EPMC8576081 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature