Comprehensive analysis of immune related lncRNAs in the tumor microenvironment of stage II-III colorectal cancer.

ABSTRACT:

Background

Long non-coding RNAs (lncRNAs) associated with immunological function have increasingly been found to act as effective prognostic biomarkers of the overall survival (OS) of colorectal cancer (CRC) patients. We sought to identify a signature of immune-related lncRNAs that offered value as a tool for the prospective prognostic evaluation of patients with stage II-III CRC.

Methods

The clinical and gene expression data of CRC patients in The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases was obtained and separated into a training cohort composed of 202 samples, a test cohort of 124 samples from the GSE72970 dataset, and a validation cohort of 91 samples from the GSE143985 dataset.

Results

We firstly evaluated intratumoral immune cell inf

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC8576234 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature