Establishment and verification of a prognostic tumor microenvironment-based and immune-related gene signature in colon cancer.

ABSTRACT:

Background

Gastrointestinal malignant cancers affect many sites in the intestinal tract, including the colon. In this study, we purposed to improve prognostic predictions for colon cancer (CC) patients by establishing a novel biosignature of immune-related genes (IRGs) based on the tumor microenvironment (TME).

Methods

Using the estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) algorithm, we calculated the stromal and immune scores of every CC patient extracted from The Cancer Genome Atlas (TCGA). We then identified 4 immune-related messenger RNA (mRNA) biosignatures through a Cox and least absolute shrinkage and selection operator (LASSO) univariate analysis, and a Cox multivariate analysis. Relationships between tumor immune

SUBMITTER: Guo T 

PROVIDER: S-EPMC8576251 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature