Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut.

ABSTRACT: Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context. Using the Drosophila midgut as a model, we have recently described that adult intestinal stem cells (ISCs), do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. How aneuploidy impacts ISCs in intestinal tumorigenic models remains to be investigated, and it represents a very important biological question to address since data from multiple in vivo models suggests that the cellular impact of aneuploidy is highly dependent on the cellular and tissue context. Using manipulation of different genetic pathways such as EGFR,

SUBMITTER: Bras R 

PROVIDER: S-EPMC8576263 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature