Disruption of Glucocorticoid Action on CD11c⁺ Dendritic Cells Favors the Generation of CD4⁺ Regulatory T Cells and Improves Fetal Development in Mice.

ABSTRACT: A wealth of innate and adaptive immune cells and hormones are involved in mounting tolerance towards the fetus, a key aspect of successful reproduction. We could recently show that the specific cross talk between the pregnancy hormone progesterone and dendritic cells (DCs) is significantly engaged in the generation of CD4⁺ FoxP3⁺ regulatory T (Treg) cells while a disruption led to placental alterations and intra-uterine growth restriction. Apart from progesterone, also glucocorticoids affect immune cell functions. However, their functional relevance in the context of pregnancy still needs clarification. We developed a mouse line with a selective knockout of the glucocorticoid receptor (GR) on DCs, utilizing the cre/flox system. Reproductive outcome and maternal immune

SUBMITTER: Diao L 

PROVIDER: S-EPMC8576435 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature