Genome analysis identifies differences in the transcriptional targets of duodenal versus pancreatic neuroendocrine tumours.

ABSTRACT:

Objective

Gastroenteropancreatic neuroendocrine tumours (GEP-NETs) encompass a diverse group of neoplasms that vary in their secretory products and in their location within the gastrointestinal tract. Their prevalence in the USA is increasing among all adult age groups.

Aim

To identify the possible derivation of GEP-NETs using genome-wide analyses to distinguish small intestinal neuroendocrine tumours, specifically duodenal gastrinomas (DGASTs), from pancreatic neuroendocrine tumours.

Design

Whole exome sequencing and RNA-sequencing were performed on surgically resected GEP-NETs (discovery cohort). RNA transcript profiles available in the Gene Expression Omnibus were analysed using R integrated software (validation cohort). Digital spatial profiling (DSP) was used to

SUBMITTER: Rico K 

PROVIDER: S-EPMC8576490 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature