Subcutaneous Adipose Tissue Metabolic Function and Insulin Sensitivity in People With Obesity.

ABSTRACT: We used stable isotope-labeled glucose and palmitate tracer infusions, a hyperinsulinemic-euglycemic clamp, positron emission tomography of muscles and adipose tissue after [¹⁸F]fluorodeoxyglucose and [¹⁵O]water injections, and subcutaneous adipose tissue (SAT) biopsy to test the hypotheses that 1) increased glucose uptake in SAT is responsible for high insulin-stimulated whole-body glucose uptake in people with obesity who are insulin sensitive and 2) putative SAT factors thought to cause insulin resistance are present in people with obesity who are insulin resistant but not in those who are insulin sensitive. We found that high insulin-stimulated whole-body glucose uptake in insulin-sensitive participants with obesity was not due to channeling of gluco

SUBMITTER: Koh HE 

PROVIDER: S-EPMC8576507 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature