Spatial and Functional Organization of Human Papillomavirus Replication Foci in the Productive Stage of Infection.

ABSTRACT: The life cycle of human papillomavirus (HPV) depends on keratinocyte differentiation as the virus modulates and takes advantage of cellular pathways to replicate its genome and assemble viral particles in differentiated cells. Viral genomes are amplified in nuclear replication foci in differentiated keratinocytes, and DNA repair factors from the DNA damage response signaling pathway are recruited to replicate viral DNA. The HPV genome is associated with cellular histones at all stages of the infectious cycle, and here, we show that the histone variant macroH2A1 is bound to the HPV genome and enriched in viral replication foci in differentiated cells. macroH2A1 isoforms play important roles in cellular transcriptional repression, double-strand break repair, and replication stress. The viral

SUBMITTER: Khurana S 

PROVIDER: S-EPMC8576538 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature