Association between serum iron status and primary liver cancer risk: a Mendelian randomization analysis.

ABSTRACT:

Background

Serum iron status has been reported as associated with primary liver cancer (PLC) risk. However, whether iron status plays a role in the development of PLC remains inconclusive.

Methods

Genetic summary statistics of the four biomarkers (serum iron, ferritin, transferrin saturation, and transferrin) of iron status and PLC were retrieved from two independent genome-wide association studies (GWAS) that had been performed in European populations. Two-sample univariate and multivariate Mendelian randomization (MR) analyses were conducted to determine the causal link between iron status and PLC risk.

Results

No significant horizontal pleiotropy was detected for the four biomarkers according to the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PR

SUBMITTER: Tian T 

PROVIDER: S-EPMC8576647 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature