Identification of aberrantly methylated-differentially expressed genes and potential agents for Ewing sarcoma.

ABSTRACT:

Background

Human DNA methylation is a common epigenetic regulatory mechanism, and it plays a critical role in various diseases. However, the potential role of DNA methylation in Ewing sarcoma (ES) is not clear. This study aimed to explore the regulatory roles of DNA methylation in ES.

Methods

The microarray data of gene expression and methylation were downloaded from the Gene Expression Omnibus (GEO) database, and analyzed via GEO2R. Venn analysis was then applied to identify aberrantly methylated-differentially expressed genes (DEGs). Subsequently, function and pathway enrichment analysis was conducted, a protein-protein interaction (PPI) network was constructed, and hub genes were determined. Besides, a connectivity map (CMap) analysis was performed to screen bioactive com

SUBMITTER: Li G 

PROVIDER: S-EPMC8576650 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature