A novel defined hypoxia-related gene signature to predict the prognosis of oral squamous cell carcinoma.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC), as the most common oral cancer globally, is very harmful to people's health. Hypoxia is closely related to many cancers. In this study, we have conducted a comprehensive exploration of the impact of hypoxia on OSCC.

Methods

First, we calculated the enrichment score (ES) of hypoxia-related genes in the sample based on the enrichment analysis of the single sample Gene Set Enrichment Analysis (ssGSEA) and expressed it as a potential hypoxia index (HPI). We first identified the relationship between HPI and survival time in OSCC tumor samples. Then we assessed the correlation between hypoxia and the degree of infiltration of various immune cells in OSCC tissues, and screened out gene mutations that may be related to HPI in OSCC. Fin

SUBMITTER: Han Y 

PROVIDER: S-EPMC8576654 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature