A novel prognostic signature for idiopathic pulmonary fibrosis based on five-immune-related genes.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a highly fatal lung disease of unknown etiology with a median survival after diagnosis of only 2-3 years. Its poor prognosis is due to the limited therapy options available as well as the lack of effective prognostic indicators. This study aimed to construct a novel prognostic signature for IPF to assist in the personalized management of IPF patients during treatment.

Methods

Differentially-expressed genes (DEGs) in IPF patients versus healthy individuals were analyzed using the "limma" package of R software. Immune-related genes (IRGs) were obtained from the ImmPort database. Univariate Cox regression analysis was adopted to screen significantly prognostic IRGs for IPF patients. Multiple Cox regression analysis was used to i

SUBMITTER: Qiu L 

PROVIDER: S-EPMC8576669 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature