The potential prognostic values of the ADAMTS-like protein family: an integrative pan-cancer analysis.

ABSTRACT:

Background

A disintegrin-like and metalloproteinase domain with thrombospondin type 1 motifs (ADAMTS)-like proteins, including ADAMTSL1-6 and papilin, which are part of the mammalian ADAMTS superfamily, appear to be relevant to extracellular matrix function and the regulation of ADAMTS protease activity. Their roles in tumor initiation and progression and regulating the tumor microenvironment (TME) are now recognized.

Methods

In the present study, a comprehensive investigation of the pan-cancer effects of ADAMTSLs and their associations with patient survival, drug responses, and the TME was performed by integrating The Cancer Genome Atlas (TCGA) data and annotated data resources.

Results

The expression of ADAMTSL family members was found to be dysregulated in many can

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8576672 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature