Changes in aortic collagen in β-aminopropionitrile-induced acute aortic dissection.

ABSTRACT:

Background

The precise role collagen plays in acute aortic dissection (AAD) was investigated in an animal model of β-aminopropinitrile (BAPN)-induced AAD.

Methods

The 30 3-week-old male specific-pathogen free (SPF)-grade Sprague-Dawley (SD) rats were randomly divided into two groups: 10 in the Control group and 20 in the Model group. The Model group was treated with 0.1% BAPN for 4 weeks, while the Control group received untreated water. Histopathological staining and western blot were used to detect changes of the extracellular matrix (ECM) and collagen content in the aorta.

Results

At the end of the experiment, the incidence of AAD was 25%, the aortic ECM of surviving rats was severely damaged, and the arrangement was disordered. Fibroblast cells are unevenly distri

SUBMITTER: Zhou H 

PROVIDER: S-EPMC8576682 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature