Magnetic resonance quantification of non-Gaussian water diffusion in hepatic fibrosis staging: a pilot study of diffusion kurtosis imaging to identify reversible hepatic fibrosis.

ABSTRACT:

Background

This study aimed to evaluate the diagnostic accuracy of diffusion kurtosis imaging (DKI) in differentiating early hepatic fibrosis (HF) from normal liver and advanced HF in rabbits.

Methods

A total of 35 healthy New Zealand white rabbits were included in the study. A model of HF was established in 30 rabbits through subcutaneous injections of 50% carbon tetrachloride (CCl₄)/olive oil, while 5 rabbits received saline injections. The gradually increased doses of CCl₄ were 0.1, 0.2, and 0.3 mL/kg in weeks 1 to 3, weeks 4 to 6, and weeks 7 to 10, respectively. Two injections were given each week. Two rabbits in the experimental group died. All rabbits underwent DKI with three b values (0, 500, and 1,000 s/mm²) at week 5 (n=8), week 6 (

SUBMITTER: Liu T 

PROVIDER: S-EPMC8576693 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature