Hippocampal CysLT1R overexpression or activation accelerates memory deficits, synaptic dysfunction, and amyloidogenesis in young APP/PS1 transgenic mice.

ABSTRACT:

Background

Our previous studies demonstrated that cysteinyl leukotrienes receptor 1 (CysLT₁R) knockout, pharmacological blockade, or hippocampus knockdown produced beneficial effects against Alzheimer's disease (AD); however, whether CysLT₁R upregulation has deleterious effects on AD remains elusive.

Methods

In this study, we investigated the changes in behaviors, hippocampal amyloidogenesis, and synapse plasticity after CysLT₁R overexpression by microinfusion of the lentiviral vector, containing its coding sequence of mouse (LV-CysLT₁R), into the bilateral dentate gyri (DG) of the hippocampus or CysLT₁R activation by repeated systemic administration of its agonist YM-17690 (0.1 mg/kg, once a day, i.p., for 28 d).

Res

SUBMITTER: Fang SC 

PROVIDER: S-EPMC8576703 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature