Increased LINC00922 in preeclampsia regulates the proliferation, invasion, and migration of placental trophoblast cells.

ABSTRACT:

Background

Recent studies have shown that the abnormal expression of long-chain non-coding RNAs (lncRNAs) can significantly affect the biological function of trophoblast cells and lead to the occurrence of preeclampsia (PE). This study explores the expression of lncRNA LINC00922 in PE and its effect on the function of placental trophoblast cells, along with the corresponding molecular mechanism, providing a theoretical basis and molecular target for understanding the occurrence, early diagnosis, and targeted therapy of PE.

Methods

Fluorescence quantitative PCR was used to detect the expression of LINC00922 in 30 cases of PE tissues and normal tissues. The CCK-8 assay, clone formation experiment, and flow cytometry were used to detect the effects of LINC00922 knockdown or ove

SUBMITTER: Gao C 

PROVIDER: S-EPMC8576713 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature