A narrative review of mechanisms of ferroptosis in cancer: new challenges and opportunities.

ABSTRACT:

Objective

This article reviews the specific mechanism of ferroptosis in cancer and introduces in detail the opportunities and challenges of ferroptosis-based cancer therapy, aiming to provide a new research direction for tumor therapy.

Background

Ferroptosis is a newly discovered programmed non-apoptotic form of cell death. Involving changes in metabolic processes and the accumulation of peroxidation caused by factors such as drugs or genes which destruct the cell membrane structure, this kind of cell death has been linked with the pathological process of diseases such as tumors, neurological diseases, ischemia-reperfusion injury, kidney injury, and hemopathy. This kind of cell death can play a vital role in inhibiting tumorigenesis by eliminating the adaptive characteristic

SUBMITTER: Jiang M 

PROVIDER: S-EPMC8576726 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature