FK506-loaded PLGA nanoparticles improve long-term survival of a vascularized composite allograft in a murine model.

ABSTRACT:

Background

The side effects of life-long administration of FK506 limit the clinical practice of vascularized composite allografts (VCAs). This study aimed to evaluate the feasibility of FK506-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (FK506 NPs) for prolonging the long-term survival of VCAs and reducing the side effects of FK506.

Methods

PLGA nanoparticles loaded with FK506 were prepared by the solvent evaporation method. The characterization of FK506 NPs was evaluated by electron microscopy. To confirm the function and safety of FK506 NPs, these particles were administrated into rats by intraperitoneal injection. The survival time of the allograft, systemic concentration of FK506, anti-rejection activity, and side-effect of FK506 NPs were evaluated in a Bro

SUBMITTER: Cao Z 

PROVIDER: S-EPMC8576731 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature