Dataset Information

N-Methyl-D-aspartate (NMDA) and cannabinoid CB₂ receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.

ABSTRACT:

Background

The cannabinoid CB₂ receptor (CB₂R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia. As NMDA receptors are the target of current medication in Alzheimer's disease patients and with the aim of finding neuromodulators of their actions that could provide benefits in dementia, we hypothesized that cannabinoids could modulate NMDA function.

Methods

Immunocytochemistry was used to analyze the colocalization between CB₂ and NMDA receptors; bioluminescence resonance energy transfer was used to detect CB₂-NMDA receptor complexes. Calcium and cAMP determination, mitogen-activ

SUBMITTER: Rivas-Santisteban R

PROVIDER: S-EPMC8576920 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

N-Methyl-D-aspartate (NMDA) and cannabinoid CB₂ receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.

Background

Methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

N-Methyl-D-aspartate (NMDA) and cannabinoid CB₂ receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors.