Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine.

ABSTRACT:

Background

Cancer is a somatic evolutionary disease and adenocarcinomas of the stomach and gastroesophageal junction (GC) may serve as a two-dimensional model of cancer expansion, in which tumor subclones are not evenly mixed during tumor progression but rather spatially separated and diversified. We hypothesize that precision medicine efforts are compromised when clinical decisions are based on a single-sample analysis, which ignores the mechanisms of cancer evolution and resulting intratumoral heterogeneity. Using multiregional whole-exome sequencing, we investigated the effect of somatic evolution on intratumoral heterogeneity aiming to shed light on the evolutionary biology of GC.

Methods

The study comprised a prospective discovery cohort of 9 and a validation cohort of

SUBMITTER: Rocken C 

PROVIDER: S-EPMC8576943 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature