Thymol-loaded PLGA nanoparticles: an efficient approach for acne treatment.

ABSTRACT:

Background

Acne is a common skin disorder that involves an infection inside the hair follicle, which is usually treated with antibiotics, resulting in unbalanced skin microbiota and microbial resistance. For this reason, we developed polymeric nanoparticles encapsulating thymol, a natural active compound with antimicrobial and antioxidant properties. In this work, optimization physicochemical characterization, biopharmaceutical behavior and therapeutic efficacy of this novel nanostructured system were assessed.

Results

Thymol NPs (TH-NP) resulted on suitable average particle size below 200 nm with a surface charge around - 28 mV and high encapsulation efficiency (80%). TH-NP released TH in a sustained manner and provide a slow-rate penetration into the hair follicle, being h

SUBMITTER: Folle C 

PROVIDER: S-EPMC8577023 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature