SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil.

ABSTRACT:

Background

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.33-derived lineage named N.9 was described recently in Brazil and it's considered a potential variant of interest (VOI) due to the presence of E484K substitution at the receptor-binding domain (RBD) of the Spike (S) protein.

Objective

To describe the first detection of variant N.9 in Rio de Janeiro State.

Methods

SARS-CoV-2 N.9 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR), whole-genome sequencing and phylogenetic analysis.

Findings

Here, we report two SARS-CoV-2 N.9 lineage strains in Rio de Janeiro. One of them had only the E484K substitution of the six N.9 lineage-defining mutations. Other three strains pre-defined as N.9 have the same

SUBMITTER: Tort LFL 

PROVIDER: S-EPMC8577066 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature