Ontology highlight
ABSTRACT:
SUBMITTER: Ma J
PROVIDER: S-EPMC8577076 | biostudies-literature | 2021 Nov
REPOSITORIES: biostudies-literature
Ma Jun J Lu Jiajia J Zhou Zhibin Z Lu Nan N He Jia J Zhu Lei L Ye Tianwen T
iScience 20211012 11
The precise effect of estrogen (E2) on osteoclast function is still poorly understood. The aim of this study was to investigate the potential role of transient receptor potential vanilloid 6 (TRPV6) in E2-mediated osteoclast function and to characterize the relevant underlying mechanisms. Here, we found that Trpv6 is drastically decreased in ovariectomy operation animals and the administration of E2 results in an increased expression of Trpv6 in osteoclasts. In contrast, Trpv6 depletion signific ...[more]