Protocol for assessing the role of hippocampal perineuronal nets in aversive memories.
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ABSTRACT:
SUBMITTER: Jovasevic V
PROVIDER: S-EPMC8577157 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Protocol for assessing the role of hippocampal perineuronal nets in aversive memories.
Jovasevic Vladimir V Zhang Hui H Petrovic Zorica Z Cicvaric Ana A Radulovic Jelena J
STAR protocols 20211102 4
Perineuronal nets (PNNs) are emerging as critical regulators of memory-related neuronal processes. However, their exact contribution depends on type of memory, consolidation stage, or brain region, and remains to be fully investigated. We describe here a protocol to evaluate the importance of PNNs in the dorsal hippocampus in different stages of aversive memories using a mouse model. The protocol provides detailed instructions for surgical implantation of hippocampal cannulas, drug infusion, con ...[more]
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