Pd-catalyzed allylative dearomatisation using Grignard reagents.

ABSTRACT: Pd-catalyzed allylative dearomatisation of naphthyl halides is shown to be feasible by employing Grignard reagents. The high reactivity of the nucleophile allows for fast reactions and low catalyst loading, while a plethora of successfully substituted compounds illustrate the broad scope. Five membered heteroaromatic compounds are also demonstrated to be reactive under similar conditions.

SUBMITTER: Boldrini C 

PROVIDER: S-EPMC8577247 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature